關於「3CL protease inhibitor」標籤，搜尋引擎有相關的訊息討論：

Lead compounds for the development of SARS-CoV-2 3CL protease ...。

2021年4月1日 · We report the identification of three structurally diverse compounds – compound 4, GC376, and MAC-5576 – as inhibitors of the SARS-CoV-2 3CL ...。

Inhibition of the 3CL Protease and SARS-CoV-2 Replication by ...。

2021年6月17日 · -E.P. performed the docking inves- tigations; A.P. performed the analysis of dalcetrapib-ester/thiol conversion; F.L.-T. managed the research ...。

3C-like protease inhibitors block coronavirus replication in vitro and ...。

3CLpro inhibitors show activity against multiple coronaviruses in enzyme and ... 2 X-ray cocrystal structures of compounds with coronavirus 3CL proteases.。

Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease ...。

2021年6月24日 · By testing reported 3CL protease inhibitors against a large collection of 3CL proteases with variable sequence similarity, we identified ...。

Biochemical screening for SARS-CoV-2 main protease inhibitors。

2020年10月6日 · The screens confirmed several known SARS-CoV Mpro inhibitors as ... main protease Mpro (also termed 3CLpro because of its homology to the ...。

High-Throughput Screening Identifies Inhibitors of the SARS ...。

A quenched fluorescence resonance energy transfer assay was developed for 3CLpro to screen the proteinase against 50,000 drug-like small molecules on a fully ...。

SARS-CoV-2 Mpro inhibitors with antiviral activity - AAAS - Science。

2021年3月26日 · This cleaving process is performed by two viral proteases: main protease (Mpro, also named 3CL protease) and papain-like protease (7). These ...。

Identification of Potential Inhibitors of 3CL Protease of SARS-CoV-2 ...。

2020年12月17日 · The 3CL protease (3CLpro) is the main protease of the SARS-CoV-2, ... In conclusion, novel 3CLpro inhibitors from the ZINC database were ...： 。

Advances in developing small molecule SARS 3CL pro inhibitors as ...。

2021年1月1日 · Overview of various protease inhibitors. •. Importance of 3CLpro enzyme for virus replication. •. 3CLpro as important target for drug ...。

Mechanism of the Maturation Process of SARS-CoV 3CL Protease。

Viral maturation requires a main protease (3CLpro) to cleave the ... of the SARS 3CLpro from the polyprotein and design of new structure-based inhibitors.